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Hereditary persistence of fetal hemoglobin : ウィキペディア英語版 | Hereditary persistence of fetal hemoglobin
Hereditary persistence of fetal hemoglobin (HPFH, BrE: ''Hereditary persistence of foetal haemoglobin'') is a benign condition in which significant fetal hemoglobin (hemoglobin F) production continues well into adulthood, disregarding the normal shutoff point after which only adult-type hemoglobin should be produced.〔http://cancerweb.ncl.ac.uk/cgi-bin/omd?hereditary+persistence+of+foetal+haemoglobin 〕 ==Causes== This is usually caused by mutations in the ''β or α'' globin gene cluster, or the γ promoter gene region. . The percentage of incorrect expression might be as low as 10-15% or as high as 100% of the total hemoglobin, usually higher in homozygotes than in heterozygotes.〔http://www.enerca.org/PublicPages/Anaemiascovered/HereditarypersistanceoffoetalhaemoglobinHPFH/tabid/177/Default.aspx 〕
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